What is the Dissolution Similarity Factor f2 Calculator?
Calculate the f2 similarity factor for two dissolution profiles. ITS Research Solution keeps the interactive tool above the explanation so you can calculate first and then review the method used.
Formula or method
f2 = 50 log10{[1 + (1/n)Σ(Rt−Tt)²]⁻0.5 × 100}.
How to use this tool
Enter the requested values using consistent units, run the calculation and review the main result plus any supporting values. Values closer to 100 indicate greater profile similarity; common regulatory interpretation often uses 50–100 when conditions are met.
Interpretation and limitations
Eligibility for f2 comparison depends on guidance-specific conditions, variability and time-point selection. Always check source data, units, rounding and discipline-specific requirements before using a result in assessed, published, regulated or high-stakes work.
Frequently asked questions
How is this result calculated?
f2 = 50 log10{[1 + (1/n)u03a3(Rtu2212Tt)u00b2]u207b0.5 u00d7 100}.
Can I use this result in formal academic or research work?
Use it as a transparent calculation aid, then verify the assumptions, units, rounding and any institution-, journal- or field-specific requirements before formal use.