What is the Dissolution Difference Factor f1 Calculator?
Calculate the f1 difference factor between reference and test dissolution profiles. ITS Research Solution keeps the interactive tool above the explanation so you can calculate first and then review the method used.
Formula or method
f1 = [Σ|Rt−Tt| / ΣRt] × 100.
How to use this tool
Enter the requested values using consistent units, run the calculation and review the main result plus any supporting values. Enter matched percentage-release values at the same sampling times.
Interpretation and limitations
Regulatory use of f1 requires appropriate sampling points and adherence to the applicable guidance. Always check source data, units, rounding and discipline-specific requirements before using a result in assessed, published, regulated or high-stakes work.
Frequently asked questions
How is this result calculated?
f1 = [u03a3|Rtu2212Tt| / u03a3Rt] u00d7 100.
Can I use this result in formal academic or research work?
Use it as a transparent calculation aid, then verify the assumptions, units, rounding and any institution-, journal- or field-specific requirements before formal use.